LY 2874455 - LM 1476

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1981

CAS [1254473-64-7]

MF C21H19Cl2N5O2
MW 444.31

Purity: 99%
Soluble in DMSO

LY 2874455

Description

Potent and selective FGFR inhibitor; LY2874455 inhibits autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 (with in vitro IC50 values of 2.8, 2.6, 6.4, and 6 nM, respectively), which is required for activation of FGF-induced downstream signaling

G Zhao et al. A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows A Potent Broad-spectrum of Anti-tumor Activity in Several Tumor Xenograft Models. Mol. Cancer Ther. 2011, 10, 2200.

AN Brooks et al. Molecular Pathways: Fibroblast Growth Factor Signaling: A New Therapeutic Opportunity in Cancer. Clin. Cancer Res. 2012, 18, 1855.

Potent and selective FGFR inhibitor

Chemical name

(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol

Parent CAS No.

[1254473-64-7]

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2 mg	€110.00	In Stock
5 mg	€160.00	In Stock

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LY 2874455 - LM 1476

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LY 2874455 - LM 1476

Description

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