Erastin

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1825

CAS [571203-78-6]

MF C30H31ClN4O4
MW 547.04

Purity: 99%
Soluble in DMSO

Erastin

Description

An anti-tumor agent with RAS-selective lethality. Erastin binds to mitochondrial voltage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating; induce non-apoptotic cell death selectively in some tumour cells harbouring activating mutations in the RAS-RAF-MEK pathway

N Yagoda et al. RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007, 447, 865-869.

Citation: JF Foley, Selective Killing. Sci. STKE 2007, 391, p. tw212.

E imamura et al. Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents. J. Bioenerg. Biomembr. 2008, 40(3), 213-217.

VDAC2 modulator

Chemical name

4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-

Parent CAS No.

[571203-78-6]

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Size	Unit Price	Stock
5 mg	€90.00	In Stock
10 mg	€130.00	In Stock
50 mg	€460.00	In Stock

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Erastin

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Erastin

Description

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