Pregabalin - PD144723

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1823

CAS [148553-50-8]

MF C8H17NO2
MW 159.23

Purity: 98%
Optical purity: Optically pure
Soluble in water

Pregabalin

Description

An analogue of γ-amino butyric acid (GABA) but inactive at GABA receptors. Pregabalin binds to the α2δ protein, an auxiliary protein associated with voltage-gated calcium channels in the central nervous system. Pregabalin reduces the synaptic release of several neurotransmitters by binding to α2δ subunits, possibly accounting for its actions in vivo to reduce neuronal excitability and seizures. Antiepileptic and analgesic.

CP Taylor et al. Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007, 73, 137–150.

Y Zhang et al. Development and validation of a direct enantiomeric separation of pregabalin to support isolated perfused rat kidney studies. J. Chrom. B. 2008, 875, 148–153.

Reduces synaptic signaling by binding to α2δ subunits

Chemical name

(S)-3-(aminomethyl)-5-methylhexanoic acid

Parent CAS No.

[148553-50-8]

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Pregabalin - PD144723

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