WAY 362450 - FXR 450 | XL 335

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1749

CAS [629664-81-9]

MF C25H24F2N2O3
MW 438.47

Purity: 99%
Soluble in DMSO

WAY 362450

Description

A highly potent, selective, and orally bioavailable farnesoid X receptor (FXR) agonist (EC50: 4 nM, eff=149%); potently induces luciferase reporter expression with an EC50 value of 16 nMpotently induces luciferase reporter expression with an EC50 value of 16 nM

B Flutt et al. Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR). J. Med. Chem. 2009, 52(4), 904–907.

MJ Evans et al. A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296(3), G543-G552.

HB Hartman et al. Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/− and apoE−/− mice. J. Lipid Res. 2009, 50(6), 1090-1100.

S Zhang et al. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J Hepatol. 2009, 51(2), 380-388.

Farnesoid X receptor (FXR) agonist

Chemical name

Isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Parent CAS No.

[629664-81-9]

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5 mg	€125.00	In Stock
25 mg	€465.00	In Stock

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WAY 362450 - FXR 450 | XL 335

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WAY 362450 - FXR 450 | XL 335

Description

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