RO 3306

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1530

CAS [872573-93-8]

MF C18H13N3OS2
MW 351.45

Purity: 99%
Soluble in DMSO

RO 3306

Description

Selective CDK 1 inhibitor (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively), which induces cell cycle arrest and actively enhances downstream p53 signaling to promote apoptosis in AML cell lines.

LT Vassilev et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci USA. 2006, 103(28), 10660–10665.

K Kojima et al. The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 2009, 100(6), 1128–1136.

List of publications using RO 3306 (Axon 1530) purchased from Axon Medchem

CDK1 inhibitor

Chemical name

5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one

Parent CAS No.

[872573-93-8]

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RO 3306

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RO 3306

Description

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Parent CAS No.

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