HMG-box
This superfamily of transcription factors with β-scaffold DNA-binding domains with minor groove contacts comprises 11 subclasses: RHR, STAT, p53, MADS box, β-Barrel α-helix transcription factors, TATA binding proteins, HMG-box, Heteromeric CCAAT factors, grainyhead, Cold-shock domain factors, and Runt[1]. Late SV40 Factor (LSF), also known as alpha-globin transcription factor CP2 (TFCP2), functions as part of the SSP(stage selector protein) complex, and binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters[2].
[1] P. Stegmaier, A.E. Kel, E. Wingender. Systematic DNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.
[2] P.K. Santhekadur et al. The transcription factor LSF: a novel oncogene for hepatocellular carcinoma. Am. J. Cancer Res. 2012, 2, 269-285.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2378 | Kartogenin | Promotor of chondrocyte differentiation from primary human MSCs | €75.00 | |