ETA

Endothelins are very potent vasoconstrictors that bind to smooth muscle endothelin receptors (GPCR-A7 subfamily), of which there are two subtypes: ETA and ETB receptors. Their activation causes the release of calcium by the sarcoplasmic reticulum (SR) and increased smooth muscle contraction and vasoconstriction. The receptors have been implicated in the pathogenesis of hypertension, coronary vasospasm, and heart failure[1].


[1] Endothelins and Endothelin Receptor Antagonists. Therapeutic Considerations for a Novel Class of Cardiovascular Drugs. T.F. Lüscher, M. Barton. Circulation. 2000, 102, 2434-2440

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Axon ID Name Description From price
1648 Ambrisentan Endothelin-A (ETA) antagonist €70.00
4058 Atrasentan Highly potent, selective, and orally active endothelin-A (ETA) antagonist €130.00

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