5-HT3
5-HT3 differ from all other 5-HT (serotonin) receptors whose actions are mediated via G proteins. Their structure and function has placed them in the Cys-loop family of cationic ligand-gated ion channels. 5-HT3 receptors are located in both the peripheral (PNS) and central (CNS) nervous systems. In the CNS, 5-HT3 receptors may play roles in a variety of functions including emesis, cognition and anxiety, whereas in the PNS they play a role in a variety of sympathetic, parasympathetic and sensory functions (e.g. signaling in gastrointestinal tract, gut motility and peristalsis)[1].
[1] 5-HT3 Receptors. A. J. Thompson, S. C. R. Lummis. Curr Pharm Des. 2006; 12(28): 3615–3630.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2534 | (+)-Azasetron hydrochloride | 5-HT3 antagonist | €135.00 | |
| 2535 | (-)-Azasetron hydrochloride | 5-HT3 antagonist | €135.00 | |
| 1097 | Alosetron hydrochloride | 5-HT3 antagonist | €85.00 | |
| 1096 | Azasetron hydrochloride | 5-HT3 antagonist | €90.00 | |
| 1153 | B-HT 920 dihydrochloride | D2 agonist, α2 adrenoceptor agonist; 5-HT3 antagonist | €75.00 | |
| 1449 | Granisetron hydrochloride | 5-HT3 antagonist | €80.00 | |
| 3101 | Palonosetron hydrochloride | Highly potent, selective and orally active 5-HT3 antagonist | €150.00 | |