Methyltransferases
Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].
[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2705 | A-196 | Potent and selective inhibitor of SUV4-20 | €105.00 | |
| 2863 | AMI-1 | Inhibitor of PRMT | €99.00 | |
| 2635 | BAY-598 | Selective inhibitor of SMYD2 | €110.00 | |
| 2735 | BCI-121 | Inhibitor of SMYD3 | €90.00 | |
| 1692 | BIX 01294 trihydrochloride | HMTase inhibitor (G9a and G9a-like protein) | €80.00 | |
| 2210 | C 7280948 | Sulfone inhibitor of PRMT1 | €85.00 | |
| 2812 | CM-272 | First-in-class potent, selective and reversible inhibitor of G9a/DNMT | Recently added | €125.00 |
| 2709 | CMP5 | Inhibitor of PRMT5 | €95.00 | |
| 1590 | Decitabine | DNA methyltransferase inhibitor | €85.00 | |
| 2701 | EED226 | Potent, selective and orally bioavailable PRC2 inhibitor | €105.00 | |
| 2831 | EPZ 015666 | Potent, selective and orally available inhibitor of PRMT5 | €125.00 | |
| 2227 | EPZ 6438 | Inhibitor of Histone Lysine Methyltransferase EZH2 | €105.00 | |
| 2140 | GSK 126 | Inhibitor of Histone Lysine Methyltransferase EZH2 | €75.00 | |
| 2710 | HLCL65 hydrochloride | Inhibitor of PRMT5 | €105.00 | |
| 2223 | Lomeguatrib | Potent, orally active inhibitor of MGMT | €135.00 | |