Dehydrogenases
A dehydrogenase enzyme (a.k.a. DHO) is an enzyme belonging to the group of oxidoreductases (EC 1.) that oxidizes a substrate by a reduction reaction that transfers one or more hydrides (H−) to an electron acceptor, usually NAD+/NADP+ or a flavincoenzyme such as FAD or FMN.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2746 | AG-120 | IDH1 mutant enzyme inhibitor | €125.00 | |
| 2745 | AG-221 | IDH2 mutant enzyme inhibitor | €95.00 | |
| 2122 | AGI 5198 | Inhibitor of R132 mutant isocitrate dehydrogenase 1 (IDH1) | €60.00 | |
| 2274 | AGI 6780 | Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q) | €90.00 | |
| 2551 | Alda 1 | Small molecule activator of ALDH2 | €65.00 | |
| 2787 | ASP 9521 | Inhibitor of 17 β–hydroxysteroid dehydrogenase type 5 | €75.00 | |
| 3863 | BAY-1436032 | Highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1) | Inquire | |
| 3638 | BAY-179 | Potent, selective, and species cross-reactive complex I inhibitor | €100.00 | |
| 2698 | BTZ043 | Antimycobacterial DprE1 inhibitor that kills Mycobacterium tuberculosis | €105.00 | |
| 1756 | BVT 2733 hydrochloride | Inhibitor of 11β-hydroxysteroid dehydrogenase type 1 | €90.00 | |
| 2585 | CBR 5884 | Noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) | €90.00 | |
| 2125 | CPI-613 | Inhibitor of mitochondrial pyruvate dehydrogenase (PDH) complex | €110.00 | |
| 3725 | CVT-10216 | Highly selective, reversible inhibitor of ALDH-2 | €110.00 | |
| 2476 | DEAB | Potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes | €50.00 | |
| 3020 | DS44960156 | Selective MTHFD2 inhibitor | €180.00 | |
| 3612 | GAPDH inhibitor compound F8 | Covalent GAPDH inhibitor | €120.00 | |
| 3621 | GSK2837808A | Potent, selective and NADH-competitive inhibitor of LDH-A | €130.00 | |
| 2909 | IACS-010759 | Potent and orally bioavailable inhibitor of complex I of oxidative phosphorylation | €95.00 | |
| 2654 | JK184 | Hedgehog (Hh) signaling pathway antagonist with antiproliferative activity | €80.00 | |
| 3915 | KOTX1 | Selective, non-cytotoxic and reversible ALDH1A3 inhibitor | €130.00 | |
| 3164 | Leflunomide | Selective inhibitor of de novo pyrimidine synthesis; DMARD | €60.00 | |
| 2480 | LW6 | Inhibitor of HIF-1α stability via MDH2 inhibition and/or binding with CHP1 | €85.00 | |
| 3880 | MCI-INI-3 | Potent and selective ALDH1A3 inhibitor | Recently added | €130.00 |
| 2623 | NCT-503 | PHGDH inhibitor that suppresses the growth of PHGDH-dependent cancer cells | €105.00 | |
| 2450 | NHI 2 | Selective cell membrane permeable inhibitor of human lactate dehydrogenase A | €90.00 | |
| 2626 | PBTZ169 | Potent irreversible DprE1 inhibitor; tuberculosis therapeutic | €95.00 | |
| 1515 | Sitamaquine | Succinate dehydrogenase inhibitor with anti-Leishmanial activity | €120.00 | |
| 3317 | Trilostane | Orally active, competitive inhibitor of 3β-hydroxysteroid dehydrogenase | €90.00 | |
| 2377 | Vidofludimus | Oral immunomodulatory drug that inhibits dihydroorotate dehydrogenase (DHODH) | €125.00 | |
| 4024 | Vorasidenib | First-in-class, potent, orally active, brain-penetrant dual mIDH1/2 | Recently added | €140.00 |