ADAMTS-5
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5; EC 3.2.24.xx) plays a role in cartilage degradation, arthritis, procollagen processing, degradation of proteoglycans, and cancer, among others. It is a member of the metzincins superfamily of zinc-based proteinases[1], and 1 of the 19 members of a family of secreted metalloproteinases in humans. ADAMTS-5, also termed ADAMTS-11, aggrecanase-2 or implantin, falls under the subfamily of proteoglycanases within the ADAMTS family. All of the members of ADAMTS family have a similar structural organization with an N-terminal metalloproteinase domain followed by various ancillary domains at the C-terminal region[2]. Several members of the ADAMTS family possess some degree of aggrecanolytic activity in vitro, including ADAMTS-5. It cleaves human aggrecan to produce the fragments found in synovial fluid and cartilage[3].
MMP subclasses listed: ADAMTS-5, TACE
[1] T. Shiomi et al. Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathol. Int. 2010, 60, 477-496.
[2] S. Kumar et al. ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity. Am. J. Pathol. 2012, 181, 1056-1068.
[3] R.H. Song et al. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum. 2007, 56, 575-585.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2083 | ADAMTS-5 inhibitor | Selective inhibitor of ADAMTS-5 (aggrecanase-2) | €140.00 | |