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Axon 2570
CAS [223387-75-5]
MF C12H9ClN2O4MW 280.66
Orally active HIF prolyl 4-hydroxylase inhibitor (P4-HI; IC50 value 3.9 μM for PHD2) that increases plasma EPO levels up to 30-fold in hemodialysis (HD) patients, and reduces cardiac remodeling after myocardial infarction in rats independent of a reduction of collagen maturation or altering growth factors.
KEYWORDS: FG-2216 | supplier | PHD inhibitor | YM 311 | FG2216 | YM311 | CAS [223387-75-5] | Hypoxia-signaling cascade | PHD (HIF) | Inhibitor | hypoxia inducible factor | prolyl hydroxylase | EPO | hemodialysis | cardiac remodeling | myocardial infarction | collagen
2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid
[223387-75-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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