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Axon 2549
CAS [325970-71-6]
MF C16H14Br2N4O4MW 486.11
Cytotoxic inhibitor of DNA ligase I and III (IC50 values 10 μM each) that binds to the DBD of hLigI, hence leading to inhibition of DNA binding and ligation and specifically sensitizes cancer cells to DNA damage. Breast cancer cell lines with acquired resistance to antiestrogen therapeutics are hypersensitive to a combination of L67 and PARP inhibitor ABT 888 (Axon 1593).
KEYWORDS: L67 | supplier | DNA ligase inhibitor | L-67 | CAS [325970-71-6] | DNA-RNA | DNA-ligase | Inhibitor | cytotoxic | breast | cancer | replication | double-strand break | DSB | DNA damage | NHEJ | ATP-dependent
2-(3,5-dibromo-4-methylphenylamino)-N'-(2-hydroxy-5-nitrobenzylidene)acetohydrazide
[325970-71-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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