Napabucasin - BBI 608 | FNQ

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2517

CAS [83280-65-3]

MF C14H8O4
MW 240.21

Purity: 99%
Soluble in DMSO

Napabucasin

Description

Oral first-in-class cancer stemness (CSCs) inhibitor that works by targeting STAT3. Napabucasin is a naturally occurring drug with enhanced toxicity versus glucose-starved tumor cells, and found to induce Mcl-1 cleavage and sustained phosphorylation of c-Jun-N-terminal kinase. Effectively blocks cancer relapse and metastasis in xenografted human cancers.

V. Kuete et al. Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants. PLoS One. 2011;6(8):e21762.

M. Rieber et al. Mcl-1 cleavage and sustained phosphorylation of c-Jun-N-terminal kinase mediate melanoma apoptosis induced by 2-acetyl furanonaphthoquinone: roles of Bcl-2 and p53. Cancer Biol Ther. 2008 Aug;7(8):1206-11.

Y. Li et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44.

Apoptosis Cell Signaling & Oncology Immunology Stem Cell Transcription Factors JAK-STAT TF class 4.2.1 STAT3

Oral first-in-class cancer stemness inhibitor that works by targeting STAT3

Chemical name

2-acetylbenzo[f][1]benzofuran-4,9-dione

Parent CAS No.

[83280-65-3]

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10 mg	€105.00	In Stock
50 mg	€405.00	In Stock

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Napabucasin - BBI 608 | FNQ

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Napabucasin - BBI 608 | FNQ

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