Inhibitor of USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes, thereby promoting the degradation of Vps34 PI3 kinase complexes. Beclin1 is a tumor suppressor and regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. Moreover, Spautin 1 inhibits autophagy which enhances imatinib-induced apoptosis in chronic myeloid leukemia. The pro-apoptotic activity of Spautin-1 was also associated with activation of GSK-3β, an important downstream effector of PI3K/AKT.

KEYWORDS: Spautin 1 | supplier | USP10-USP13 inhibitor | MBCQ derivative C43 | Spautin1 | CAS [1262888-28-7] | Ubiquitin | Deubiquitinase | Beclin 1 | Vps34 | PI3K | Akt | p53 | apoptosis | autophagy | GSK-3β