Class I selective HDAC inhibitor (sub-micromolar IC50 values for HDAC1, HDAC2, and HDAC11, ca 2 μM for HDAC3, and >10 μM for HDAC4-8) with broad spectrum antitumor activity in vitro and in vivo. MGCD 0103 induced hyperacetylation of histones, selectively induced apoptosis, caused cell cycle blockade, and exhibited potent and selective antiproliferative activities against a broad spectrum of human cancer cell lines in vitro.

KEYWORDS: Mocetinostat | Supplier | HDAC inhibitor | MGCD 0103 | MG 0103 | MG0103 | MGCD0103 | CAS [726169-73-9] | Histone | HDAC1 | HDAC2 | HDAC3 | HDAC11 | deacetylase | antitumor | hyperacetylation | apoptosis | cell cycle | blockade | isotype-selective