TBPB

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2463

CAS [634616-95-8]

MF C25H32N4O
MW 404.55

Purity: 100%
Soluble in DMSO

TBPB

Description

Selective allosteric activator of the M1 muscarinic acetylcholine receptor (EC50 value 20 nM at hM1-WT) devoid of M2-M5 activity. TBPB increases non-amyloidogenic APP processing and produces antipsychotic-like effects in rodent models predictive of antipsychotic-like activity.

C.K. Jones et al. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 2008 Oct 8;28(41):10422-33. doi: 10.1523/JNEUROSCI.1850-08.2008.

M.A. Jacobson et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from.... Mol Pharmacol. 2010 Oct;78(4):648-57.

T.M. Bridges et al. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5439-42.

CNS CHRM1 A18

Allosteric activator of the M1 acetylcholine receptor devoid of M2-M5 activity.

Chemical name

1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

Parent CAS No.

[634616-95-8]

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TBPB

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