Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 µM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.
KEYWORDS: NG 25 trihydrochloride | supplier | TAK1 (MAP3K7) and MAP4K2 inhibitor | NG25 | CAS [2108554-00-1] | [1315355-93-1] | MAPK | MAP3K | MAP4K | Lck | RAF | ERK | IKKβ | LYN | CSK | Abl | FER | p38α | SRC | NF-kappaB | TNF | Interferon | Immunology | PDC | Toll like | TLR | Inhibitor | Enzymes