BMS 833923 - XL 139

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2356

CAS [1059734-66-5]

MF C30H27N5O
MW 473.57

Purity: 99%
Soluble in DMSO

BMS 833923

Description

Oral, small molecule antagonist of the Hedgehog (Hh) signaling component Smoothened (SMO). Treatment with BMS 833923 leads to a decreased expression of GLI1 and PTCH1 in EGI-1 cells, reduced tumor growth in vitro, and a prolongation of survival in vivo in different human cancers. Additionally, SMO inhibition by BMS 833923 leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells (EACs).

T.L. Lin et al. Hedgehog pathway as a drug target: Smoothened inhibitors in development. Onco. Targets Ther. 2012, 5, 47-58.

J. Brechbiel et al. Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer. Cancer Treat. Rev. 2014, 40, 750-759.

D. Riedlinger et al. Hedgehog pathway as a potential treatment target in human cholangiocarcinoma. J. Hepatobiliary Pancreat. Sci. 2014, 21, 607-615.

A.H. Zaidi et al. Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells. Cancer Invest. 2013, 31, 480-489.

Oral antagonist of the Hedgehog signaling component Smoothened (SMO)

Chemical name

N-(2-methyl-5-((methylamino)methyl)phenyl)-4-(4-phenylquinazolin-2-ylamino)benzamide

Parent CAS No.

[1059734-66-5]

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Size	Unit Price	Stock
5 mg	€75.00	In Stock
25 mg	€225.00	In Stock

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BMS 833923 - XL 139

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