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Axon 2351
CAS [1380432-32-5]
MF C25H30N6OMW 430.55
EHop 016 is a Rac GTPase inhibitor (IC50 value 1.1 µM) specific for Rac1 and Rac3 at concentrations of 5 µM, and inhibits the interaction of Vav2 with Rac1 at physiologically relevant concentrations. Moreover, EHop-016 inhibits the activation of the Rac downstream effector p21-activated kinase (PAK), extension of motile actin-based structures, and cell migration. EHop-016 is ~100 times more potent than NSC 23766 (Axon 1578) and 10–50 times more potent than other currently available Rac inhibitors.
N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine
[1380432-32-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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