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Axon 2348
CAS [1351761-44-8]
MF C19H21F4N5O3MW 443.40
Highly potent, selective, metabolically stable, and brain-penetrable LRRK2 inhibitor (IC50 value 9 nM for phospho-LRRK2 in vitro). GNE 7915 is selective across 187 screened kinases, and >3200 and 53 times selective over JAK2 and TTK, respectively. GNE 7915 does not suppress LPS-stimulated TNFα and CXCL10 levels in LPS-treated primary wild-type (WT) or knockout (KO) astrocyte cultures, and is not reported to cause cellular or genetic toxicity.
(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-5-ethoxyphenyl)(morpholino)methanone
[1351761-44-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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