BAY 60-6583 - BR 4887

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2317

CAS [910487-58-0]

MF C19H17N5O2S
MW 379.44

Purity: 99%
Soluble in DMSO

BAY 60-6583

Description

Potent and highly selective A2BAR (Adenosine) agonist (Ki value 0.33-0.75 nM, species dependent). BAY 60-6583 potently stimulated cAMP production in HEK 293 cells expressing mouse A2BARs (EC50 value 2.83 nM), and BAY 60-6583 produced a biphasic effect on fMLP-stimulated superoxide production.

J.A. Auchampach et al. Characterization of the A2B adenosine receptor from mouse, rabbit, and dog. J Pharmacol Exp Ther. 2009 Apr;329(1):2-13.

D. van der Hoeven et al. A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. J Pharmacol Exp Ther. 2011 Sep;338(3):1004-12.

S. Hinz et al. BAY60-6583 acts as a partial agonist at adenosine A2B receptors. J Pharmacol Exp Ther. 2014 Jun;349(3):427-36.

Potent and highly selective A2BAR (Adenosine) agonist

Chemical name

2-(6-amino-3,5-dicyano-4-(4-(cyclopropylmethoxy)phenyl)pyridin-2-ylthio)acetamide

Parent CAS No.

[910487-58-0]

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Size	Unit Price	Stock
10 mg	€125.00	In Stock
50 mg	€475.00	In Stock

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BAY 60-6583 - BR 4887

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BAY 60-6583 - BR 4887

Description

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