Evacetrapib - LY 2484595

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2286

CAS [1186486-62-3]

MF C31H36F6N6O2
MW 638.65

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

Evacetrapib

Description

Potent, and selective inhibitor of cholesteryl ester transfer protein (CETP; IC 50 value 5.5 nM and 26 nM in human recombinant and plasme CETP assays, respectively) that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.

G. Cao et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J. Lipid Res. 2011, 52, 2169-2176.

D.G. Johns et al. On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of CETP inhibitors. Drugs. 2012, 72, 491-507.

N.B. Mantlo et al. Update on the discovery and development of cholesteryl ester transfer protein inhibitors for reducing residual cardiovascular risk. J. Med. Chem. 2014, 57, 1-17.

Potent, and selective inhibitor of CETP

Chemical name

trans-(1S,4r)-4-(((S)-5-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid

Parent CAS No.

[1186486-62-3]

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Evacetrapib - LY 2484595

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Evacetrapib - LY 2484595

Description

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