SF 1670

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2186

CAS [345630-40-2]

MF C19H17NO3
MW 307.34

Purity: 98%
Soluble in DMSO

SF 1670

Description

Inhibitor of phosphatase and tensin homologue deleted on chromosome 10 (PTEN, IC50 value 2 µM), an important regulator of insulin-dependent signaling, that augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. SF 1670 enhances neutrophil functions and fMLP-induced PtdIns(3,4,5)P3 signaling in neutrophils. SF 1670 is also a potent inhibitor of protein tyrosine phosphatase (PTP) CD45 (aka PTPRC; IC50 values 0.2 µM and 0.1 µM for CD45 induced pNPP hydrolysis and T-cell proliferation, respectively) and of galactokinase (GALK, IC50 value 0.7 µM).

Y. Li et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011, 117, 6702-6713.

R.A. Urbanek et al. Potent reversible inhibitors of the protein tyrosine phosphatase CD45. J. Med. Chem. 2001, 44, 1777-1793.

E. Rosivatz et al. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem. Biol. 2006, 1, 780-790.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Diabetes & Metabolism p53-Tumor Suppression PI3K-Akt-mTOR PTEN PTPRC GALK EC 3.1.3.67

Inhibitor of PTEN with significant inhibitory effect on PTPRC and GALK

Chemical name

N-(9,10-dioxo-9,10-dihydrophenanthren-2-yl)pivalamide

Parent CAS No.

[345630-40-2]

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