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CPI 613

 

 

CAS 95809-78-2

C22H28O2S2  MW 388.59

Purity: 100%

Soluble in basic aq. solution

Soluble in DMSO

 

 

 

 

Ordering Information:

 

Cat. No. Axon 2125    NEW 

 

Qty1: 10 mg / 105  $137

Promotion: 2 x 10 mg  @  160  $208

Qty2: 50 mg / 350  $455

Qty3: on request

 

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for payment and tech support.

 

Certificate of Analysis (CoA): current batch 
Safety Data Sheet (MSDS):  view

 

 

Biological Activity:

 

A small molecular inhibitor of a mitochondrial enzyme pyruvate dehydrogenase (PDH) complex; CPI-613 selectively attacks the regulatory aspects of tumor cell mitochondrial metabolism, activating both apoptotic (programmed cell death) and non-apoptotic (necrosis-like) cell death pathways.

 

References:

 

Z Zachar et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J. Mol. Med. (Berl). 2011, 89(11), 1137-1148. [online]

 

KC Lee et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab. Lett. 2011, 5(3), 163-182. [online]

 

 

Chemical Name: 6,8-Bis(benzylthio)octanoic acid

 

CPI 613 | PDH inhibitor | Axon 2125 | CPI613 from supplier Axon Medchem

Axon Ligands TM  - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com 2013

 

Axon Ligands in The Field:

 

CPI 613 | PDH inhibitor

 

 

See Featured Cell Signaling and Oncology Ligands from Axon Ligands Collection