A small molecular inhibitor of a mitochondrial enzyme pyruvate dehydrogenase (PDH) complex; CPI-613 selectively attacks the regulatory aspects of tumor cell mitochondrial metabolism, activating both apoptotic (programmed cell death) and non-apoptotic (necrosis-like) cell death pathways.
Z Zachar et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J. Mol. Med. (Berl). 2011, 89(11), 1137-1148. [online]
KC Lee et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab. Lett. 2011, 5(3), 163-182. [online]
Chemical Name: 6,8-Bis(benzylthio)octanoic acid