Levonorgestrel

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2065

CAS [797-63-7]

MF C21H28O2
MW 312.45

Purity: 99%
Soluble in DMSO

Levonorgestrel

Description

A second generation synthetic progestogen used as an active ingredient in some hormonal contraceptives; binds to the progesterone receptor (PR) as an agonist; a synthetic progesterone steroid that displays potent progestional and androgenic effects but it lacks estrogen-like activity

H von Hertzen et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. The Lancet, 2002, 360(9348), 1803-1810.

AE Lemus et al. Mechanism of action of levonorgestrel: In vitro metabolism and specific interactions with steroid receptors in target organs. J. Steroid Biochem. Mol. Biol. 1992, 41(3), 881-890.

Progesterone receptor (PR) agonist

Chemical name

(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

Parent CAS No.

[797-63-7]

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