Linezolid - Zyvox | PNU 100766 | U 100766

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2048

CAS [165800-03-3]

MF C16H20FN3O4
MW 337.35

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Linezolid

Description

Protein synthesis inhibitor; antibiotic; stops the growth of bacteria by disrupting their production of proteins; inhibits the ribosomal peptidyltransferase; antibacterial agent for the treatment of multidrug-resistant gram-positive bacterial infections

SJ Brickner et al. Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J. Med. Chem. 2008, 51(7), 1981-1990.

MR Barbachyn, CW Ford. Oxazolidinone structure-activity relationships leading to linezolid. Angew. Chem. Int. Ed. Engl. 2003, 42(18), 2010-23.

SJ Brickner et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. J. Med. Chem. 1996, 39(3), 673-9.

U Patel et al. Oxazolidinones mechanism of action: inhibition of the first peptide bond formation. J. Biol. Chem. 2001, 276(40), 37199-205.

CE Barry and JS Blanchard. The Chemical Biology of New Drugs in Development for Tuberculosis. Curr. Opin. Chem. Biol. 2010, 14(4), 456–466.

Protein synthesis inhibitor; antibiotic

Chemical name

(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Parent CAS No.

[165800-03-3]

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Linezolid - Zyvox | PNU 100766 | U 100766

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Linezolid - Zyvox | PNU 100766 | U 100766

Description

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Parent CAS No.

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