Sildenafil citrate - Viagra | UK 92480

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2046

CAS [171599-83-0]

MF C22H30N6O4S.C6H8O7
MW 666.70

Purity: 100%
Soluble in DMSO

Sildenafil citrate

Description

Potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) with IC50 value of 4 nM; Enhances nitric oxide (NO)-dependent relaxation of human corpus cavernosum in vitro; an oral therapy for erectile dysfunction (ED)

M Boolell et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int. J. Impot. Res. 1996, 8 (2), 47–52.

I Goldstein et al. Oral Sildenafil in the Treatment of Erectile Dysfunction. N. Engl. J. Med. 1998, 338, 1397-1404.

Inhibitor of cGMP-specific PDE5

Chemical name

5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 2-hydroxypropane-1,2,3-tricarboxylate

Parent CAS No.

[139755-83-2]

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Sildenafil citrate - Viagra | UK 92480

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