Atorvastatin calcium - Lipitor

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2043

CAS [134523-03-8]

MF C33H34FN2O5.0.5Ca
MW 577.67

Purity: 99%
Soluble in DMSO

Atorvastatin calcium

Description

An inhibitor of HMG-CoA reductase (statin) indicated as an adjunct therapy to diet to lower the LDL ("bad") cholesterol and triglycerides in your blood. It can raise your HDL ("good") cholesterol as well.

BD Roth. The Discovery and Development of Atorvastatin, a Potent Novel Hypolipidemic Agent. Prog. Med. Chem. 2002, 40, 1–22.

S Youssef et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002, 420, 78-84.

HM Colhoun et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet, 2004, 364 (9435), 685 - 696.

PS Sever et al. Prevention of Coronary and Stroke Events with Atorvastatin in Hypertensive Patients who have Average or Lower-than-Average Cholesterol Concentrations, in the Anglo-Scandinavian Cardiac (...). Drugs 2004, 64 (2 Suppl.), 43-60.

JC LaRosa et al. Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease. N. Engl. J. Med. 2005, 352, 1425-1435.

Inhibitor of HMG-CoA reductase

Chemical name

(3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate hemi-calcium salt

Parent CAS No.

[134523-00-5]

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