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Axon 1934
CAS [1373422-53-7]
MF C22H23N5O2MW 389.45
The first selective and potent histone demethylase JMJD3/UTX inhibitor; blocks demethylation of histone H3K27; showed no activity against a panel of JMJ family demethylases and 100 protein kinases.Available also a cell permeable ethyl ester derivative GSK J4 (Axon 1933), which is a prodrug suitable for cell-based studies and will be hydrolyzed to GSK-J1 in cells rapidly
3-(6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic acid
[1373422-53-7]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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