GSK 2636771 dihydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1912

CAS [2108806-07-9]

MF C22H22F3N3O3.2HCl
MW 506.35

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

GSK 2636771 dihydrochloride

Description

Potent, orally available and specific PI3K p110β (PI3K beta, PI3Kβ) inhibitor

RA Rivero, MA Hardwick. Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of phosphatidylinositol 3-kinase-beta (PI3Kβ) for the treatment of PTEN deficient tumors. Cancer Res. 2012, 72(8 Supplement), 2913.

RM Sanchez et al. Synthesis and structure–activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors. Bioorg. Med. Chem. Lett. 2012, 22(9), 3198-3202.

H Lin. Isoform Selective PI3K-beta Inhibitors. Chin. J. Chem. 2013, 31(3), 299-303.

PI3K inhibitor (p110 β specific)

Chemical name

2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid dihydrochloride

Parent CAS No.

[1372540-25-4]

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Size	Unit Price	Stock
5 mg	€105.00	In Stock
25 mg	€360.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€520.00	In Stock

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