PKI 587 - PF 05212384 | Gedatolisib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1807

CAS [1197160-78-3]

MF C32H41N9O4
MW 615.73

Purity: 99%
Moderately soluble in DMSO

PKI 587

Description

Highly potent PI3K/mTOR kinase inhibitor; PKI-587 inhibits PI3K-α, β, γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively. PKI-587 inhibits mTOR TOC1 kinase activity in human MDA-MB-361 cells assessed as surppression of 4EBP1 phosphorylation at <30 nM; PKI-587 inhibits Akt S473 phosphorylation in human MDA-MB-361 cells and Akt T308 phosphorylation in human MDA-MB-361 cells with IC50 of 8nM and 10 nM

R Mallon et al. Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor. Clin Cancer Res. 2011, 17(10), 3193-203.

R Gedaly et al. PKI-587 and Sorafenib Targeting PI3K/AKT/mTOR and Ras/Raf/MAPK Pathways Synergistically Inhibit HCC Cell Proliferation. J. Surg. Res. 2011, 1-7.

AM Venkatesan et al. Bis(morpholino-1,3,5-triazine) derivatives: Potent adenosine 5’-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: Discovery of compound 26 (PKI-587) (...). J. Med. Chem. 2010, 53, 2636.

Dual PI3K and mTOR inhibitor

Chemical name

1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea

Parent CAS No.

[1197160-78-3]

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5 mg	€90.00	In Stock
25 mg	€270.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€420.00	In Stock

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PKI 587 - PF 05212384 | Gedatolisib

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PKI 587 - PF 05212384 | Gedatolisib

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