NVP-BKM120 | PI3K inhibitor | Axon Medchem

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NVP-BKM120 - BKM 120

CAS 944396-07-0

C18H21F3N6O2 MW 410.39

Purity: >98%

Solubel in DMSO to 92 mM

Ordering Information:

Cat. No. Axon 1797 Prime Source

Qty1: 5 mg (research sample) / 145 $189

Promotion: 2 x 5 mg / 220 $286

Qty2: 25 mg (research sample) / 545 $709

Promotion: 2 x 25 mg / 760 $988

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent, selective, orally bioavailable class I PI3K inhibitor

References:

MT Burger et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med. Chem. Lett. 2011, 2(10), 774779. [online]

D Koul et al. Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells. Clin Cancer Res. 2012, 18(1), 184-195. [online]

Chemical Name: 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine

NVP-BKM120 | PI3K inhibitor | Axon Medchem | Axon 1797 | BKM 120