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AMG 900

CAS 945595-80-2

C28H21N7OS  MW 503.15

Purity: >98%

Soluble in DMSO to 50 mM 

Ordering Information:

Cat. No. Axon 1783        Prime Source

Qty1: 5 mg (research sample) / €135  $176

Promotion: 2 x 5 mg @ €200  $260

Qty2: 25 mg (research sample) / €435  $566

Promotion: 2 x 25 mg @ €660  $858

Qty3: on request contract research synthesis

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Biological Activity:   Potent and highly selective inhibitor of pan-aurora kinases with activity in taxane-resistant tumor cell lines.     References:   MN Payton et al. Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010, 70(23), 9846-9854. [online]    L Huang et al. In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases. Xenobiotica. 2011, 41(5), 400-408. [online]     Chemical Name: N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine

AMG 900 | Aurora inhibitor | Axon Medchem | Axon 1783 | AMG900

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