GDC 0980 - RG 7422 | GNE 390 | Apitolisib

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1782

CAS [1032754-93-0]

MF C23H30N8O3S
MW 498.60

Purity: 99%
Soluble in DMSO

GDC 0980

Description

Selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms and apparent Ki of 17.3 nM for human mTOR. GDC-0980 has excellent pharmacokinetic and pharmaceutical properties and demonstrates broad activity in xenograft cancer models (breast, ovarian, lung, and prostate)

JJ Wallin et al. GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway. Mol. Cancer Ther. 2011, 10(12), 2426-2436.

AJ Wagner et al. A first-in-human phase I study to evaluate GDC-0980, an oral PI3K/mTOR inhibitor, administered QD in patients with advanced solid tumors. J. Clin. Oncol. 2011, 29 (suppl; abstr 3020).

DP Sutherlin et al. Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer. J. Med. Chem. 2011, 54(21), 7579-87.

Dual PI3K and mTOR inhibitor

Chemical name

(S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one

Parent CAS No.

[1032754-93-0]

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Size	Unit Price	Stock
5 mg	€80.00	In Stock
25 mg	€250.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€120.00	In Stock
2 x 25 mg	€380.00	In Stock

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GDC 0980 - RG 7422 | GNE 390 | Apitolisib

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GDC 0980 - RG 7422 | GNE 390 | Apitolisib

Description

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Parent CAS No.

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