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Nav1.7 blocker 52

Compound 52 in ref. 1 - TC-N 1752

CAS 1211866-85-1

C25H27F3N6O3  MW 516.52

Purity: 99%

Soluble in DMSO to 66 mM

Ordering Information:

Cat. No. Axon 1780    Prime Source

Qty1: 10 mg / €145  $189 

Qty2: 50 mg / €545  $709 

Qty3: on request

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Biological Activity:   Potent and state-dependent sodium channel blocker, selective at voltage-gated Nav1.7 (SCN9A); Selectivity over many ion channels and GPCRs, including some selectivity within the sodium channel family.   References:   H Bregman et al. Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J. Med. Chem. 2011, 54(13), 4427-4445. [online]       Chemical Name: N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

Nav1.7 blocker 52 | Axon 1780 | Axon Medchem | TC-N 1752 - TC-N1752

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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