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AZ 960

CAS 905586-69-8

C18H16F2N6  MW 354.14

Purity: 99% (optically pure) 

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1778    Prime Source Promotion

Qty1: 2 mg (research sample) / €125  $163

Qty2: 5 mg (research sample) / €185  $241

Qty3: on request contract research synthesis

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Biological Activity:   Potent, selective and ATP competitive JAK2 inhibitor; AZ960 inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell.   References:   JM Gozgit et al. Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2. J. Biol. Chem. 2008, 283(47), 32334-32343. [online]   J Yang et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010, 9(12), 3386-3395. [online]       Chemical Name: (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile

AZ 960 | JAK2 inhibitor | Axon Medchem | Axon 1778 | AZ960

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