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Bardoxolone Methyl - CDDO-Me  

- CDDO Methyl ester - RTA 402

CAS 218600-53-4

C32H43NO4  MW 505.69

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1772    Prime Source

Qty1: 5 mg (research sample) / €145  $189

Promotion: 2 x 5 mg @ €220  $286

Qty2: 25 mg (research sample) / €545  $709

Promotion: 2 x 25 mg @ €820  $1066

Qty3: on request

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Biological Activity:   Orally-available antioxidant inflammation modulator (AIM), being the most potent known inducer of the Nrf2 pathway; induces apoptosis of human tumor cells by disruption of redox balance and directly blocks IKKβ activity and thereby the NF-κB pathway.     References: online   R Ahmad et al. Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179. J. Biol. Chem. 2006, 281, 35764-35769. [online]     M Konopleva et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 2002, 99(1), 326-335. [online]   R Ahmad et al. Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation. Mol. Cancer Res. 2010, 8(7), 986-993. [online]     Chemical Name: Methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate

Bardoxolone Methyl - CDDO-Me | Axon Medchem | Axon 1772 | CDDO-Methyl ester - RTA 402

Axon LigandsTM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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