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AMG 706 - Motesanib diphosphate 

CAS 857876-30-3

C22H23N5O.2H3PO4  MW 569.44

Purity: 99%

Soluble in water and DMSO 

Ordering Information:

Cat. No. Axon 1768    Prime Source

Qty1: 5 mg (research sample) / €145  $189

Promotion: 2 x 5 mg  / €220  $286 

Qty2: 25 mg (research sample) / €450  $585

Promotion: 2 x 25 mg  / €720  $936 

Qty3: on request contract research synthesis

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Biological Activity:   A potent and orally bioavailable multiple receptor tyrosine kinase inhibitor, targeting VEGFR/PDGFR/c-KIT (IC50: 2, 3, 6, 84, 8 and 59 nm for VEGFR1, VEGFR2, VEGFR3, PDGFR, KIT and Ret receptors resepectively); potently inhibits angiogenesis and induces regression in tumor xenografts.   References: online   A Polverino et al. AMG 706, an Oral, Multikinase Inhibitor that Selectively Targets Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit Receptors, Potently Inhibits Angiogenesis and Induces Regression in Tumor Xenografts. Cancer Res. 2006, 66, 8715. [online]   A Coxon et al. Broad Antitumor Activity in Breast Cancer Xenografts by Motesanib, a Highly Selective, Oral Inhibitor of Vascular Endothelial Growth Factor, Platelet-Derived Growth Factor, and Kit Receptors. Clin. Cancer Res. 2009, 15, 110. [online]     Chemical Name: N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4- ylmethyl)amino]pyridine-3-carboxamide diphosphate

AMG 706 - Motesanib | VEGFR inhibitor | Axon Medchem | Axon 1768 | AMG706

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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