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SA 4503

CAS 165377-44-6

C23H32N2O2.2HCl  MW 441.43

Purity: 99%

Water soluble to 86 mM

Ordering Information:

Cat. No. Axon 1767    2012 Promotion

Qty1: 10 mg / €125  $163

Qty2: 50 mg / €450  $585

Qty3: on request

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Biological Activity:   Potent and selective sigma-1 receptor agonist; showing high affinity (IC50=17.4 nM) for sigma-1 and 100 fold less affinity for sigma-2.   References: online   K Matsuno et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur. J. Pharmacol. 1996, 306(1-3), 271–279. [online]  G Skuza and Z Rogóz. The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. J. Physiol. Pharmacol. 2006, 57(2), 217–229. [online]       Chemical Name: 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride

SA 4503 | Sigma-1 agonist | Axon Medchem | Axon 1767 | SA4503

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Axon Ligands In The Field:

SA 4503 | Sigma-1 agonist

BD-1047 | Sigma-1 antagonist

PB 28 | Sigma-2 agonist

Axon Ligands ^TM

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.