|
Biological Activity:
Potent and specific inhibitor of Cdc2-like kinase (Clk) family (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively); a valuable tool to dissect the regulatory mechanisms involving serine/arginine-rich protein phosphorylation signaling pathways in vivo, and potential for the therapeutic manipulation of abnormal splicing.
References:
M Muraki et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004, 279(23), 24246-24254. [online]
A Nishida et al. Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Nature Commun. 2011, 2, 308. [online]
Chemical Name: (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
|
