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CoPo 22

CAS 606101-83-1

C22H22N4O2 MW 374.44 

Purity: 99%

Soluble in DMSO to 32 mM

Ordering Information:

Cat. No. Axon 1763   Prime Source Promotion

Qty1: 5 mg / €125  $163

Qty2: 25 mg / €375  $488

Qty3: on request

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Biological Activity:   Corrector and potentiator (Co-Po) for ∆F508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel function in cystic fibrosis, with low micromolar EC50.   References:   PW Phuan et al. Cyanoquinolines with Independent Corrector and Potentiator Activities Restore ∆F508-CFTR Chloride Channel Function in Cystic Fibrosis. Mol. Pharmacol. 2011, 80(4), 683-693. [online]   AS Verkman et al. CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis. Curr. Pharm. Des. 2006; 12(18), 2235-2247. [online]     Chemical Name: N-(2-((3-Cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-3-methoxybenzamide

CoPo 22 | CFTR CoPo | Axon Medchem | Axon 1763

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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