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GSK 1120212  - JTP 74057 - Trametinib

CAS 871700-17-3

C26H23FIN5O4  MW 615.39 

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1761   Prime Source

Qty1: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €180  $234

Qty2: 25 mg (research sample) / €425  $553

Promotion: 2 x 25 mg @ €640  $832

Qty3: on request

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Biological Activity:   Highly potent and selective MEK inhibitor, with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life.   References: AG Gilmartin et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin. Cancer Res. 2011, 17(5), 989-1000. [online] T Yamaguchi et al. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol. 2011, 39(1), 23-31. [online]   H Abe et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med. Chem. Lett., 2011, 2(4), 320–324. [online]     Chemical Name: N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide

GSK 1120212 | MEK inhibitor | Axon Medchem | Axon 1761 | GSK1120212

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

Axon Ligands In This Field:

AZD 6244 | MEK inhibitor

PD 184352 | MEK inhibitor

PD 0325901 | MEK inhibitor

SL 327 | MEK inhibitor