GSK 1120212 - Trametinib | JTP 74057

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1761

CAS [871700-17-3]

MF C26H23FIN5O4
MW 615.39

Purity: 99%
Soluble in DMSO

GSK 1120212

Description

Highly potent and selective MEK inhibitor, with IC50 values to be 0.7 and 0.9 nM for MEK1 and MEK2 respectively and with long circulating half-life

AG Gilmartin et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin. Cancer Res. 2011, 17(5), 989-1000.

T Yamaguchi et al. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol. 2011, 39(1), 23-31.

H Abe et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med. Chem. Lett., 2011, 2(4), 320–324.

MEK1 and MEK2 inhibitor

Chemical name

N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide

Parent CAS No.

[871700-17-3]

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5 mg	€70.00	In Stock
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GSK 1120212 - Trametinib | JTP 74057

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Parent CAS No.

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GSK 1120212 - Trametinib | JTP 74057

Description

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Parent CAS No.

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