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EGFR inhibitor [879127-07-8]

EGFR inhibitor 324674

CAS 879127-07-8 

C21H18F3N5O  MW 413.40

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1760   Prime Source 

Qty1: 5 mg (research sample) / €125  $163

Qty2: 25 mg (research sample) / €375  $488

Qty3: on request

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Biological Activity:   A potent, cell permeable, irreversible and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nM range.   References:  online   Q Zhang et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. J. Am. Chem. Soc. 2006, 128(7), 2182-2183. [online]   K Okamoto et al. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer Res. 2010, 70(24), 10402-10410. [online] Z Yu et al. Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway. Biochem. Biophys. Res. Commun. 2011, 411(4), 751-756. [online]     Chemical Name: N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino phenyl]cyclopropanecarboxamide

EGFR inhibitor [879127-07-8] | Axon 1760 | Axon Medchem

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Fields:

BIBW 2992 | EGFR/HER2 inhibitor

CI 1033 | EGFR inhibitor

CP 724714 | HER2 inhibitor

EGFR inhibitor [879127-07-8]

Erlotinib | EGFR inhibitor

Gefitinib | EGFR inhibitor

Lapatinib | EGFR/HER2 inhibitor

Neratinib | EGFR/HER2 inhibitor

OSI 420 | EGFR inhibitor

Pelitinib | EGFR inhibitor

Vandetanib | VEGFR/EGFR inhibitor

WZ 4002 | EGFR T790M inhibitor