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HMR 1098

HMR 1883 sodium salt

CAS 261717-22-0

C19H21ClN3NaO5S2  MW 493.96

Purity: >98%

Water soluble to 100 mM

Ordering Information:

Cat. No. Axon 1757    Exclusive Promotion

Qty1: 5 mg / €115  $150 

Qty2: 25 mg / €345  $449 

Qty3: on request

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Biological Activity:   KATP channel blocker; HMR 1098 acts by inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. HMR 1098 is an inhibitor of Kir6.2/SUR1-composed K(ATP) channels.   References: online   H Gögelein et al. Effects of the cardioselective KATP channel blocker HMR 1098 on cardiac function in isolated perfused working rat hearts and in anesthetized rats during ischemia and reperfusion. Naunyn Schmiedebergs Arch Pharmacol. 2001, 364(1), 33-41. [online]  HX ZHang et al. HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels. J. Mol. Cell Cardiol. 2011, 50(3), 552-560. [online]     Chemical Name: Sodium (5-(2-(5-chloro-2-methoxybenzamido)ethyl)-2-methoxyphenylsulfonyl)(methylcarbamothioyl)amide

HMR 1098 | KATP channel blocker | Axon Medchem  | Axon 1757 | HMR1098 - HMR 1883 sodium salt

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