Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

SCH 530348 - Vorapaxar 

MK 5348

CAS 618385-01-6

C29H33FN2O4  MW 492.58

Purity: 99%

Soluble in DMSO to 88 mM

Ordering Information:

Cat. No. Axon 1755      Exclusive Promotion

Qty1: 5 mg (research sample) / €155  $202

Qty2: 25 mg (research sample) / €580  $754

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for payment and tech support.

Biological Activity:   Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR-1) antagonist (Ki: 8.1 nM) that inhibits thrombin-induced platelet activation.   References: online   S Chackalamannil et al. Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity. J. Med. Chem. 2008, 51(11), 3061–3064. [online]   J Oestreich. SCH-530348, a thrombin receptor (PAR-1) antagonist for the prevention and treatment of atherothrombosis. Curr. Opin. Investig. Drugs. 2009, 10(9), 988-996. [online]     Chemical Name: Ethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl carbamate

SCH 430348 - Vorapaxar | PAR1 antagonist | Axon Medchem | Axon 1755 | SCH430348

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com © 2011