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Biological Activity:
Highly potent and selective chemokine CXCR4 receptor antagonist, with IC50 values to be 0.02-0.13 and >25 μM for CXCR4 and all other chemokine receptors respectively); HIV inhibitor; an immunostimulant used to multiply hematopoietic stem cells in cancer patients.
References: online
E De Clercq et al. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. agents chemother. 1994, 38(4), 668–74. [online]
SL Davies et al. Plerixafor Hydrochloride. Drugs Fut. 2007, 32(2), 123. [online]
AF Cashen et al. AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent. Future Oncol. 2007, 3(1), 19–27. [online]
G Calandra et al. AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data. Bone Marrow Transplantation 2008, 41, 331–338. [online]
Chemical Name: 1,1′-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride
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