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Kv1.3 blocker 42

 

 

CAS 1201582-43-5

C28H35FN2O4.HCl  MW 519.05

Purity: 99%

Water soluble up to 100 mM

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1735    Exclusive Promotion

 

Qty1: 5 mg (research sample) / €135  $176 

 

Qty2: 25 mg (research sample) / €405  $527 

 

Qty3: on request contract research synthesis

 

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or by fax to: +31-50-3600390.

 

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Biological Activity:

 

Potassium channel blocker, selective in blocking the Kv1.3 current (IC50: <50 nM); Selectivity: 25-fold over Kv1.1 and 24-fold over Kv1.5.

 

References: online

 

AJ Harvey et al. Preparation of benzoxazole compounds as potassium channel blockers. WO 2009149508.

 

 

 

 

Chemical Name: 1-(7-(3-(4-fluorophenyl)butoxy)-2,4-dimethyl-6-(2-(piperidin-1-yl)ethoxy)benzo[d]oxazol-5-yl)ethanone hydrochloride
 

Kv1.3 blocker 42 | Axon Medchem  | Axon 1735

 

Axon LigandsTM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

 

Chromanol 293B | K chan. blocker

DMP 543 | K channel blocker

HMR 1098 | KATP chan. blocker

Kv1.3 blocker | Axon 1735

PNU 37883 | KATP chan. blocker

S9947 | IKur channel blocker

XE 991 | KCNQ channel blocker

 

BMS 204352 | K channel opener

1-EBIO | KCa channel opener

NN 414 | KATP channel opener

Retigabine | KCNQ chan. opener

 

 

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