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BMS 345541

CAS 547757-23-3  

C14H17N5.HCl  MW 291.78

Purity: 99%

Soluble in water and DMSO

Ordering Information:

Cat. No. Axon 1731     Prime Source Promotion

Qty1: 5 mg / €105  $137

Qty2: 10 mg / €145  $189

Qty3: 50 mg / €545  $709

Qty4: on request

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Biological Activity:   A cell-permeable and highly selective IKB kinase (IKK) inhibitor, binds at allosteric site of the enzyme; blocks NF-kB-dependent transcription in mice; Displays ~10-fold greater selectivity at IKK-2 over IKK-1.   References:   JR Burke et al. BMS-345541 is a highly-selective inhibitor of IkB kinase, binds at an Allosteric site of the enzyme, and blocks NF-kB-dependent transcription in mice. J Biol Chem. 2003, 278(3), 1450-1456. [online]   J Yang et al. BMS-345541 Targets Inhibitor of κB Kinase and Induces Apoptosis in Melanoma: Involvement of Nuclear Factor κB and Mitochondria Pathways. Clin. Cancer Res. 2006, 12, 950. [online]     Chemical Name: N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine hydrochloride

BMS 345541 | IKK inhibitor | Axon Medchem | Axon 1731 | BMS345541

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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